| 张凯悦,李良喜,袁心怡,冀旭.藏药独一味化学成分、药理作用研究进展及质量标志物预测分析[J].,2025,34(5):84-91 |
| 藏药独一味化学成分、药理作用研究进展及质量标志物预测分析 |
| Research Progress of Chemical Composition and Pharmacological Action of Zang Medicine and Predictive Analysis of Quality Markers |
| 投稿时间：2024-07-03 |
| DOI： |
| 中文关键词: 独一味 藏药 化学成分 药理作用 质量标志物 |
| 英文关键词: Lamiophlomis rotata Zang Medicine Chemical Constituent Pharmacological Activity Quality Markers |
| 基金项目:西藏自治区自然科学基金青年项目 (ZRKX2024000320);西藏民族大学青年学人培育项目(24MDX01) 。 |
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| 中文摘要: |
| 独一味Lamiophlomis rotata (Benth.) Kudo是藏族习用药，其成分主要包括黄酮类、环烯醚萜类、苯乙醇苷类、挥发油类等，具有镇痛、止血、保护神经系统、抗肿瘤活性等药理活性。文章系统总结了国内外文献报道，就独一味化学成分、药理作用进行整理讨论。另外，基于独一味质量控制现况，结合中药质量标志物(Q-marker)的核心概念，从传统功效、传统药性、复方配伍环境、成分可测性四个方面对独一味的Q-marker进行预测分析，推测山栀苷甲酯、8-O-乙酰山栀苷甲酯、毛蕊花糖苷、木犀草素可作为独一味质量标志物的候选化合物。通过以上内容的整理，以期为藏药独一味的现代化研究、资源开发利用及质量评价体系建立提供科学的参考依据。 |
| 英文摘要: |
| Lamiophlomis rotata (Benth.) Kudo is a traditional Tibetan medicine . Its components mainly include flavonoids ,iridoids ,phenylethanol glycosides ,volatile oils ,etc .It has pharmacological activities such as analgesic ,hemostatic ,nervous system protection and anti - tumor activity.This paper systematically summarized the domestic and foreign literature reports ,and summarized and discussed the chemical constituents and pharmacological effects of the L.rotata.In addition , based on the status of quality control of single ingredient ,combined with the core concept of traditional Chinese medicine quality marker (Q - marker) ,the prediction and a- nalysis of single ingredient Q - marker were carried out from four aspects : traditional efficacy , traditional property , compound compati- bility environment and component testability. It is suggested that the candidate compounds for a single quality marker could be pyrrhine methyl ester , 8 - O - acetylpyrrhine methyl ester , verminoside and luteolin. Through the collation of the above contents , it is expected to provide scientific reference for the modernization research , resource development and utilization and the establishment of quality e- valuation system of L. rotata. |
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