| 杨飞燕,甘龙禹.自拟土家族平喘汤联合西药治疗中重度慢性
阻塞性肺疾病急性加重40例临床观察[J].,2023,32(1):93-97 |
| 自拟土家族平喘汤联合西药治疗中重度慢性
阻塞性肺疾病急性加重40例临床观察 |
| Clinical Observations of Tujia Pingchuan Decoction Combined with Western Medicinein the Treatment of Acute Exacerbation of Moderate and Severe Chronic Obstructive Pulmonary Disease |
| 投稿时间：2022-05-05 |
| DOI： |
| 中文关键词: 土家族平喘汤 慢性阻塞性肺疾病急性加重 炎症指标 血气分析 |
| 英文关键词: Tujia Pingchuan Decoction Acute Exacerbation of Chronic Obstructive Pulmonary Disease Inflammatory Index Blood Gas Analysis |
| 基金项目:湖南省中医药科研计划项目（2021127）。 |
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| 中文摘要: |
| 目的：观察自拟土家族平喘汤联合西药对中重度慢性阻塞性肺疾病急性加重患者的临床疗效。方法：选择80例中重度慢性阻塞性肺疾病急性加重患者，随机分为对照组和观察组。对照组采用常规抗感染、化痰及雾化解痉对症治疗，观察组在对照组用药基础上加服土家族平喘汤，两组均持续治疗14d。对比两组治疗前、后炎症指标(C反应蛋白、白介素-8)、血气分析指标的变化、临床疗效及不良反应发生率。结果：治疗前两组炎症指标、血气分析指标差异无统计学意义（P>0.05)，治疗后两组炎症指标水平显著低于治疗前，观察组效果更显著（P<0.05)；治疗后两组动脉血二氧化碳分压（PaCO）水平均较前下降（P<0.05），动脉血氧分压（PaO2）水平均较治疗前升高（P<0.05）。观察组总有效率优于对照组总有效率，差异具有统计学意义（P<0.05）。两组均未发生严重不良反应。结论：自拟土家族平喘汤与西药联用能抑制炎症反应，具有协同效应。 |
| 英文摘要: |
| Objective To explore the effect of Tujia Pingchuan decoction combined with western medicine with clinical efficacy.Methods 80 patients with acute exacerbation of moderate and severe chronic obstructive pulmonary disease were selected in our hospitaland they were randomly divided into control group and observation group. The control group was treated with routine anti infection,aerosol antispasmodic and expectorant symptomatic treatment. The observation group was treated with antiasthmatic Decoction on thebasis of treatment for the control group. The treatment lasted 14 days. The changes of inflammatory indexes (C -reactive protein andinterleukin -8), blood gas analysis indexes and the incidence of adverse reactions were compared between the two groups before andafter treatment. Result There was no difference in the inflammatory indexes and blood gas analysis indexes between the two groups be-fore treatment (P >0.05). The levels of inflammatory indexes in the two groups after treatment were substantially lower than those be-fore treatment, indicative of significant experimental efficacy (P <0.05). After the treatment, the level of arterial blood carbon dioxidepartial pressure (PaCO2) in the two groups decreased compared with that before the treatment (P < 0.05), and the improvement inthe experimental group was better than that in the control group (P <0.05) . The level of arterial partial pressure of oxygen (PaO2)was higher than that before treatment (P <0.05). The total effective rate of the observation group was better than that of the controlgroup (P <0.05). During the treatment, no severe adverse responses occurred in both groups. Conclusion Tujia Pingchuan decoc-tion combined with western medicine can inhibit inflammatory reaction, has synergistic effect. |
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