倪修红 邹 红.川芎嗪治疗重型脑动脉瘤的观察[J].,2014,(18):55-56 |
川芎嗪治疗重型脑动脉瘤的观察 |
Theobservationoftheeffectofligustrazineintreatmentofseverecerebralaneurysm |
修订日期:2014-07-20 |
DOI: |
中文关键词: 【关键词】川芎嗪 重型脑动脉瘤 临床观察 |
英文关键词: Keywords:Ligustrazine severecerebralaneurysm NF-κBexpression |
基金项目: |
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中文摘要: |
【摘 要】目的:探讨川芎嗪对重型脑动脉瘤患者临床疗效。方法:回顾性分析38例重症脑动脉瘤患者的临床资料,根据辅助治疗
方法的不同分为观察组23例和对照组15例,对比分析两组的临床疗效。结果:观察组患者术后经川芎嗪治疗,NF-κB表达明显低于对照
组,差异具有统计学意义(P<005)。两组患者均用弹簧圈栓塞成功。观察组患者总有效率为8690%,明显高于对照组,差异具有统计
学意义(P<005)。死亡的4例患者中,3例为脑血管痉挛,1例为肺部感染。结论:川芎嗪可以明显降低重型脑动脉瘤患者内NF-κB表
达,改善患者的愈后,降低死亡率,值得临床推广应用。 |
英文摘要: |
ObjectiveToExploretheligustrazineclinicalefficacyinpatientswithseverecerebralaneurysms.Methodsretrospec
tiveanalysisofclinicaldatainourhospitalfrom2008Januaryto2014Januaryweretreated38casesofseverecerebralaneurysm.Re
sultsthepatientsintheobservationgroupafterTMPtreatment,NF-κBsignificantlylowerthanthecontrolgroup,bycomparison,P
<005,thedifferencewasstatisticallysignificant.TwogroupsofpatientswereembolizedsuccessfullyGDC.Patientsintheobserva
tiongroupthecurerateis565%,significantlyhigherthanthatinthecontrolgroup,bycomparison,P<005,thedifferencewas
statisticallysignificant.4deathcasesofpatients,3casesofcerebralvasospasm,1casesofpulmonaryinfection.ConclusionLigus
trazinecouldsignificantlyreducetheexpressionofNF-κBinseverecerebralaneurysmpatients,improvepatientprognosis,reduce
mortality,itisworthyofclinicalapplication. |
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